Related Experiment Videos
[Orofacial alpha herpesvirus infection].
1Second Department of Oral and Maxillofacial Surgery, Tokushima University School of Dentistry.
Nihon Rinsho. Japanese Journal of Clinical Medicine
|April 25, 2000
Summary
Herpes simplex virus (HSV) commonly infects the mouth, mimicking aphthous stomatitis. While oral acyclovir
Area of Science:
- Oral medicine
- Virology
- Oncology
Context:
- The mouth is a frequent site for primary and recurrent herpes simplex virus (HSV) infections.
- Recurrent intraoral HSV infections clinically resemble aphthous stomatitis.
- HSV reactivation is observed in bone marrow transplantation, particularly after total body irradiation.
Purpose:
- To review the clinical presentation, reactivation patterns, and therapeutic strategies for oral herpes simplex virus infections.
- To explore the potential of HSV as a therapeutic agent for epithelial tumors.
Summary:
- Recurrent oral HSV infections present similarly to aphthous stomatitis.
- HSV reactivation is more common in bone marrow transplant patients receiving total body irradiation.
- Topical acyclovir effectively treats recurrent HSV lesions, though its prophylactic effect on herpes labialis is unconfirmed.
- Replication-competent HSV shows promise for treating upper aerodigestive tract epithelial cancers.
Impact:
- Highlights the diagnostic challenge of differentiating intraoral HSV from aphthous stomatitis.
- Informs management of HSV in immunocompromised patients, such as bone marrow transplant recipients.
- Suggests novel oncolytic viral therapy strategies for epithelial malignancies.