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Related Experiment Videos

The human recurrent laryngeal nerve during the aging process.

T Nakai1, N Goto, H Moriyama

  • 1Department of Oto-rhino-laryngology, Nihon University School of Medicine, Tokyo, Japan.

Okajimas Folia Anatomica Japonica
|April 25, 2000
PubMed
Summary

Aging human recurrent laryngeal nerves show axon changes, including loss of large axons and thinning of remaining ones. This study provides novel insights into age-related vocal fold nerve alterations.

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Area of Science:

  • Neuroscience
  • Aging Research
  • Otolaryngology

Background:

  • The human recurrent laryngeal nerve (RLN) is crucial for phonation.
  • Age-related changes in nerve structure can impact vocal function.

Purpose of the Study:

  • To investigate age-associated morphometric alterations in human RLN axons.
  • To document changes in nerve fiber size and number during the aging process.

Main Methods:

  • Morphometric analysis of nerve fibers.
  • Microscopic examination of human recurrent laryngeal nerve samples.

Main Results:

  • Significant disappearance of large-diameter axons was observed.
  • A general slenderization (thinning) of all remaining axons was noted.

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  • These findings represent a novel observation in aging RLN.

    • Conclusions:

    • Aging leads to specific structural modifications in human RLN axons.
    • The observed axon changes may contribute to age-related voice disorders.
    • Further research is warranted to understand the functional implications of these findings.