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[Meperidine (pethidine) outdated as analgesic in acute pancreatitis]
T van Voorthuizen1, J H Helmers, M M Tjoeng
1Afd. Interne Geneeskunde, Ziekenhuis Eemland, Amersfoort.
Nederlands Tijdschrift Voor Geneeskunde
|April 25, 2000
Summary
Meperidine is not the best choice for acute pancreatitis pain relief due to side effects. Opioids with a wider therapeutic range are preferred for managing pancreatitis pain.
Area of Science:
- Gastroenterology
- Pharmacology
Background:
- Acute pancreatitis pain is severe and often requires opioid analgesics.
- Meperidine is frequently chosen due to a perceived lesser spasmogenic effect on the sphincter of Oddi.
Purpose of the Study:
- To evaluate the efficacy and safety of meperidine versus other opioids for acute pancreatitis pain management.
- To assess the spasmogenic effect of meperidine on the sphincter of Oddi.
Main Methods:
- Literature review of opioid effects in acute pancreatitis.
- Analysis of clinical data on meperidine's side effect profile.
Main Results:
- All opioids, including meperidine, cause sphincter of Oddi spasm.
- Meperidine has unfavorable side effects like myoclonias and histamine release.
- No evidence suggests meperidine's spasmolytic effect is superior or beneficial in acute pancreatitis.
Conclusions:
- Meperidine's side effect profile is unfavorable for acute pancreatitis.
- Opioids with a broader therapeutic index are recommended over meperidine.