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Related Concept Videos

Introduction to Psychological Disorders01:19

Introduction to Psychological Disorders

Abnormal behavior, often referred to as mental illness, results from changes in brain function that influence thought patterns, behaviors, and social interactions. Psychologists and psychiatrists typically assess abnormal behavior using three primary criteria: deviance, maladaptation, and personal distress, particularly when these traits persist over long periods.
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Deviance in behavior refers to actions or thought patterns that significantly diverge from societal norms or...
Obsessive-Compulsive Disorder01:28

Obsessive-Compulsive Disorder

Obsessive-compulsive disorder (OCD) is a mental health condition characterized by recurrent obsessions, compulsions, or both, which consume significant time and interfere with daily functioning. Obsessions involve persistent, intrusive, and unwanted thoughts, images, or urges that evoke anxiety. Common examples include irrational fears of contamination or harm. Compulsions are repetitive behaviors or mental acts performed to reduce the anxiety caused by obsessions. For instance, individuals...
Anorexia Nervosa01:28

Anorexia Nervosa

Anorexia nervosa is a complex and severe eating disorder characterized by an intense fear of weight gain, an unrelenting pursuit of thinness, and a distorted body image. It often leads to dangerously low body weight relative to an individual's age and height. This disorder is marked by significant physical and psychological consequences, making it one of the most life-threatening psychiatric illnesses.
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Bulimia Nervosa01:30

Bulimia Nervosa

Bulimia nervosa is a complex and severe eating disorder characterized by a cyclical pattern of binge-and-purge eating pattern. It generally involves an episode of binge eating, followed by compensatory behaviors such as vomiting, excessive exercise, laxative use, or fasting, to prevent weight gain. Despite often maintaining a normal weight, individuals with bulimia are intensely preoccupied with their body image and harbor an overwhelming fear of gaining weight. This can contribute to the...
Binge Eating Disorders01:23

Binge Eating Disorders

Binge eating disorder is a significant mental health condition characterized by recurrent episodes of excessive food consumption within a short period, accompanied by a perceived loss of control over eating behavior. Unlike occasional overeating, binge eating disorder is marked by distressing emotions such as guilt, shame, and anxiety following binge episodes. The disorder affects individuals across different ages and backgrounds, with profound implications for physical and psychological...
Borderline Personality Disorder01:25

Borderline Personality Disorder

Borderline Personality Disorder is a complex and multifaceted mental health condition characterized by pervasive instability in interpersonal relationships, self-image, emotions, and impulse control. This instability manifests in extreme emotional reactions, fear of abandonment, and self-destructive behaviors. The disorder significantly impacts daily functioning, often leading to distress in both personal and professional domains.
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Related Experiment Video

Updated: Jul 13, 2026

Using the Activity-based Anorexia Rodent Model to Study the Neurobiological Basis of Anorexia Nervosa
07:46

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Published on: October 22, 2015

Anorexia and bulimia nervosa.

W H Kaye1, K L Klump, G K Frank

  • 1University of Pittsburgh, School of Medicine, Department of Psychiatry, Western Psychiatric Institute and Clinic, Pennsylvania 15213, USA. kayewh@msx.upmc.edu

Annual Review of Medicine
|April 25, 2000
PubMed
Summary

Anorexia nervosa (AN) and bulimia nervosa (BN) involve abnormal eating and weight regulation, influenced by genetics and personality. Neurotransmitter disturbances may play a role in these serious eating disorders.

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Area of Science:

  • Psychiatry
  • Neuroscience
  • Genetics

Background:

  • Anorexia nervosa (AN) and bulimia nervosa (BN) are eating disorders characterized by abnormal weight regulation and distorted perceptions of weight and body shape.
  • Etiologic research highlights significant genetic influences and biological contributions to the development of AN and BN.

Purpose of the Study:

  • To explore the etiology and pathogenesis of anorexia nervosa and bulimia nervosa.
  • To investigate the role of personality traits and neurobiological factors in eating disorders.
  • To review the established efficacy of treatments for AN and BN.

Main Methods:

  • Review of etiological research on eating disorders.
  • Analysis of studies on personality traits (obsessional, perfectionistic, anxious) as premorbid factors.
  • Examination of neuroendocrine, neuropeptide, and neurotransmitter system functioning in patients with AN and BN.

Main Results:

  • Substantial genetic influence and biological factors contribute to the development of AN and BN.
  • Obsessional, perfectionistic, and anxious personality styles may be premorbid traits.
  • Disturbances in neuroendocrine, neuropeptide, and neurotransmitter systems may contribute to the etiology and maintenance of these disorders.

Conclusions:

  • Eating disorders like AN and BN have significant biological and genetic underpinnings.
  • Neurobiological system disturbances are implicated in the development and persistence of these conditions.
  • Psychological treatments and pharmacotherapy are more established for BN than for AN.