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Current concepts in cobalamin deficiency.

R Carmel1

  • 1Department of Medicine, New York Methodist Hospital, Brooklyn 11215, USA. rcarmel@pol.net

Annual Review of Medicine
|April 25, 2000
PubMed
Summary
This summary is machine-generated.

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Sensitive metabolic tests reveal mild, preclinical cobalamin deficiency, common in the elderly and treatable with cobalamin. Careful interpretation of results is crucial, as not all abnormalities indicate deficiency.

Area of Science:

  • Biochemistry
  • Clinical Nutrition
  • Geriatrics

Background:

  • Mild, preclinical cobalamin deficiency is increasingly recognized, particularly in the elderly.
  • Sensitive metabolic tests have improved the identification of this deficiency state.
  • This deficiency can manifest subclinically and may affect neurological function.

Purpose of the Study:

  • To discuss the identification and implications of mild, preclinical cobalamin deficiency.
  • To highlight the role of metabolic tests in diagnosing cobalamin status.
  • To explore the causes, management, and clinical impact of preclinical cobalamin deficiency.

Main Methods:

  • Utilizing sensitive metabolic tests like the deoxyuridine suppression test.
  • Measuring levels of homocysteine and methylmalonic acid.

Related Experiment Videos

  • Analyzing clinical data to understand causes and consequences of cobalamin deficiency.

    • Main Results:

    • Preclinical cobalamin deficiency is identifiable through metabolic markers and responds to cobalamin therapy.
    • Malabsorptive disorders, particularly food-cobalamin malabsorption, are a significant cause.
    • Unusual presentations, including neurological symptoms and deficiency in neonates, are being identified.

    Conclusions:

    • Mild, preclinical cobalamin deficiency is a common condition, especially in the elderly, that requires careful diagnosis and management.
    • Metabolic testing aids in identifying this deficiency, but results necessitate cautious interpretation.
    • Understanding the causes and clinical impact of cobalamin deficiency offers opportunities for prevention and improved patient outcomes.