Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Gap junction modulation by extracellular signaling molecules: the thymus model.

L A Alves1, O K Nihei, P C Fonseca

  • 1Departamento de Imunologia, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, RJ, Brasil. alveslaa@gene.dbbm.fiocruz.br

Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Medicas E Biologicas
|April 25, 2000
PubMed
Summary

Gap junctional intercellular communication (GJIC) is vital for cell coordination and is modulated by extracellular signals. The thymus gland serves as a model to study how neuropeptides and hormones regulate GJIC in thymic epithelial cells.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Morphometric evaluation of the linea alba in fresh corpses.

JPRAS open·2024
Same author

Estrangulated obturatory hernia. Case report of a challenging diagnosis of obstructive syndrome.

International journal of surgery case reports·2024
Same author

Bone anchor as fixation method for abdominal wall reconstruction. A case report about a ten times recurred inguinal hernia.

International journal of surgery case reports·2023
Same author

The influence of simultaneous pancreas-kidney transplantation on the evolution of diabetic foot lesions and peripheral arterial disease.

Journal of endocrinological investigation·2023
Same author

Systolic dysfunction by two-dimensional speckle tracking echocardiography in dogs with parvoviral enteritis.

Journal of veterinary cardiology : the official journal of the European Society of Veterinary Cardiology·2021
Same author

Clostridium difficile toxins or infection induce upregulation of adenosine receptors and IL-6 with early pro-inflammatory and late anti-inflammatory pattern.

Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas·2020

Area of Science:

  • Cell biology
  • Neuroendocrinology
  • Immunology

Background:

  • Gap junctions form channels for direct intercellular molecular exchange, crucial for cell coordination, proliferation, and differentiation.
  • Extracellular soluble factors, including hormones and growth factors, are known to modulate gap junctional intercellular communication (GJIC).

Purpose of the Study:

  • To discuss the general modulation of GJIC by extracellular messengers.
  • To specifically examine the regulation of GJIC within the thymus gland.
  • To review recent findings on neuropeptides and hormones influencing GJIC in thymic epithelial cells.

Main Methods:

  • Review of existing literature on GJIC modulation.
  • Focus on studies investigating extracellular messenger effects.

Related Experiment Videos

  • Analysis of data related to thymic epithelial cell communication.

    • Main Results:

    • GJIC is a fundamental process influenced by a variety of extracellular signaling molecules.
    • The thymus gland exhibits complex regulation of GJIC by neuroendocrine and immune factors.
    • Neuropeptides and hormones play significant roles in modulating GJIC in thymic epithelial cells.

    Conclusions:

    • The thymus gland is a valuable model for understanding the intricate modulation of GJIC by diverse extracellular messengers.
    • Bidirectional neuroimmunoendocrine control of the thymus highlights its role in studying non-classical signaling circuits affecting cell communication.