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13:41

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Cross-reactive T-helper responses in patients infected with different subtypes of human immunodeficiency virus type 1

A C Leandersson1, G Gilljam, M Fredriksson

  • 1Karolinska Institute, Swedish Institute for Infectious Disease Control, S-171 82 Solna, Sweden. Ann-Charlotte.Leandersson@smi.ki.se

Journal of Virology
|April 25, 2000
PubMed

Immunization with a recombinant glycoprotein 160 envelope immunogen derived from a virus of genetic subtype B induced strong specific T-helper cell responses in asymptomatic human immunodeficiency virus (HIV) carriers infected with subtypes B to G. This indicates that the HIV-specific T-helper immunity, which is the basis for development of antibodies and cytotoxic T lymphocytes, can be improved by both homologous and heterologous antigens. It also suggests that a particular immunogen can be effective against many different HIV strains.

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