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Related Experiment Videos

Serum intercellular adhesion molecule-1 levels and histologic chorioamnionitis.

A Steinborn1, C Sohn, A Scharf

  • 1Department of Obstetrics and Gynecology, J.-W. Goethe-University of Frankfurt, Frankfurt/Main, Germany. Steinborn@em.uni-frankfurt.de

Obstetrics and Gynecology
|April 25, 2000
PubMed
Summary

Intercellular adhesion molecule-1 (ICAM-1) is a more effective biomarker than C-reactive protein (CRP) or white blood cell (WBC) count for diagnosing histologic chorioamnionitis in women experiencing preterm labor. This finding aids in better clinical management of preterm labor complications.

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Area of Science:

  • Obstetrics and Gynecology
  • Clinical Chemistry
  • Infectious Diseases

Background:

  • Histologic chorioamnionitis is a significant complication associated with preterm labor.
  • Accurate and early diagnosis of chorioamnionitis is crucial for effective management and improved maternal-fetal outcomes.
  • Biomarkers such as C-reactive protein (CRP) and white blood cell (WBC) count are commonly used, but their diagnostic accuracy may be limited.

Purpose of the Study:

  • To evaluate and compare the diagnostic utility of serum intercellular adhesion molecule-1 (ICAM-1) against CRP and WBC count for detecting histologic chorioamnionitis.
  • To determine which biomarker offers superior sensitivity and specificity in identifying this condition in women with preterm labor.

Main Methods:

  • Maternal blood samples were collected from women experiencing preterm delivery (<37 weeks' gestation) and a control group delivering at term.

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  • Serum levels of ICAM-1, CRP, and WBC counts were measured in all participants prior to delivery.
  • Diagnostic performance (sensitivity and specificity) of each biomarker was calculated using established cutoffs.

    • Main Results:

    • Histologic chorioamnionitis was identified in 48% of women with preterm labor.
    • Maternal serum levels of ICAM-1, CRP, and WBC counts were significantly elevated in women with histologic chorioamnionitis compared to those without.
    • ICAM-1 demonstrated higher sensitivity (98.0%) and specificity (93.8%) compared to CRP (75.5%, 71.4%) and WBC count (63.3%, 61.2%) for diagnosing histologic chorioamnionitis.

    Conclusions:

    • Serum ICAM-1 is a more reliable and accurate diagnostic marker for histologic chorioamnionitis in women with preterm labor than CRP or WBC count.
    • The findings suggest that ICAM-1 could be a valuable tool for improving the diagnosis and management of preterm labor-associated infections.