Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

[Does local regional anesthesia exert an immunosuppressive effect?].

Annales De L'Anesthesiologie Francaise

|January 1, 1976

Summary

This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Canadian journal of psychiatry. Revue canadienne de psychiatrie·2025

Same author

Mitochondrial biochemical activities and heteroplasmy evolution in established D. subobscura cell line.

In vitro cellular & developmental biology. Animal·2006

Same author

Distribution of the C282Y and H63D polymorphisms in hereditary hemochromatosis patients from the French Basque Country.

Annals of hematology·2004

Same author

Genetic hemochromatosis is a rare disease entity among French Basques: a center-based study from the general hospital of Basque County.

Annals of hematology·2001

Same author

Reduced incidence and prevalence of atopy in rheumatoid arthritis. Results of a case-control study.

Rheumatology (Oxford, England)·2000

Same author

Characteristics of deaths in a department of oncohaematology within a general hospital. A study of 81 cases.

Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer·2000

Same journal

[Study of cellular immunity by the nuclear refringence test during general anesthesia].

Annales de l'anesthesiologie francaise·1981

Same journal

[Pharmacology of fazadinium (AH 8165)].

Annales de l'anesthesiologie francaise·1981

Same journal

[Pharmacology of dobutamine].

Annales de l'anesthesiologie francaise·1981

Same journal

[Bacterial resistance to antibiotics].

Annales de l'anesthesiologie francaise·1981

Same journal

[Management of a multi-injured patient with severe closed chest injuries].

Annales de l'anesthesiologie francaise·1981

Same journal

[Preoperative nutritional state in 40 patients with digestive cancer. Effect of surgery and two different protocols for parenteral nutrition].

Annales de l'anesthesiologie francaise·1981

See all related articles

High doses of lignocaine (a local anesthetic) can suppress immune function. In patients receiving spinal anesthesia, lymphocyte transformation is reduced for a week, though less than with general anesthesia.

Area of Science:

Immunology
Anesthesiology
Pharmacology

Context:

Investigating the in vitro and in vivo immunomodulatory effects of lignocaine.
Evaluating the impact of lignocaine on lymphocyte transformation in surgical patients undergoing spinal anesthesia.

Purpose:

To determine if lignocaine exhibits immunodepressant properties.
To compare the in vivo immunodepressive effects of spinal anesthesia with lignocaine to general anesthesia.

Summary:

Lignocaine demonstrates immunodepressant properties in vitro at very high concentrations.
In vivo studies show diminished lymphocyte transformation for one week post-spinal anesthesia with lignocaine.
The observed immunosuppression is less pronounced compared to general anesthesia.

Related Experiment Videos

Impact:

Provides insights into the potential immunological consequences of high-dose lignocaine use in anesthesia.
Highlights differences in immune response between regional and general anesthesia.
Informs clinical practice regarding anesthetic choices and potential effects on patient immunity.