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Multidrug resistant Salmonella.

R Gandhi1, D D Banker

  • 1Department of Pathology, Sir Hurkisondas Nurrotumdas Hospital, Mumbai.

Indian Journal of Medical Sciences
|April 25, 2000
PubMed
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Salmonella typhi remains the most frequent cause of enteric fever in Mumbai. Alarmingly, multidrug resistance is increasing, with quinolone derivatives showing the most effectiveness against resistant strains.

Area of Science:

  • Microbiology
  • Infectious Diseases
  • Public Health

Background:

  • Enteric fever, primarily caused by Salmonella species, poses a significant public health challenge.
  • Understanding the circulating serotypes and their antimicrobial resistance patterns is crucial for effective treatment and control.

Purpose of the Study:

  • To characterize Salmonella strains isolated from enteric fever cases in Mumbai.
  • To assess the antibiotic susceptibility profiles and resistance transfer mechanisms of these strains.

Main Methods:

  • Isolation and identification of Salmonella strains using standard biochemical and serological tests.
  • Bacteriophage typing, antibiotic sensitivity testing, and conjugation experiments were performed.
  • Analysis of 326 strains collected over a two-year period (May 1992-July 1994).

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Main Results:

  • Salmonella typhi was the predominant serotype (75.46%), followed by S. paratyphi A (9.5%), S. typhimurium (5.52%), and others.
  • A high prevalence of multidrug resistance was observed, particularly against chloramphenicol, ampicillin, and cotrimoxazole.
  • Conjugation experiments indicated direct and en bloc transfer of resistance patterns.
  • Ciprofloxacin demonstrated the highest efficacy among tested drugs.

Conclusions:

  • Salmonella typhi continues to be the leading cause of enteric fever in the region.
  • There is a concerning rise in multidrug-resistant Salmonella strains, necessitating careful antibiotic selection.
  • Quinolone derivatives represent a promising therapeutic option for multidrug-resistant enteric fever.