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Humoral and cell mediated immune responses in patient with tuberculous meningitis
H A Kamat1, M Williamson, G V Koppikar
1Department of Microbiology, Topiwala National Medical Medical College, Mumbai. hakamat@xtra.co.nz
Indian Journal of Medical Sciences
|April 25, 2000
Abstract:
A study was carried out to find out the humoral and cell mediated immunity levels in patients with TBM and healthy controls. For humoral immunity, the amounts of immunoglobulins--IgG, IgM and IgA were quantitated by SRID method. For cell mediated immunity, percentages of total T cells, Th cells and Ts cells and the ratio of Th:Ts cells was studied. Hypergammaglobulinemia of all three immunoglobulins was observed together with a decrease in the total T cells and Th cells, and a lower Th:Ts cell ratio indicating a deficiency or a defect in the immune system of patients infected with TBM.