Search research articles

Related Concept Videos

Targeted Cancer Therapies

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...

Treatment Resistant Cancers

Treatment Resistant Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...

Treatment Resistent Cancers

Treatment Resistent Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...

Pulmonary Tuberculosis V

Pulmonary Tuberculosis V

Medical management of tuberculosis (TB) patients involves a comprehensive approach that includes diagnosis, treatment, and monitoring. The specific strategies can vary depending on the type of tuberculosis (latent or active), the patient's overall health status, and other considerations.
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the progression...

Curing Methods

Curing Methods

Concrete members with a small surface-to-volume ratio are cured by oiling and moistening the forms before casting the concrete member. These forms can be left in place for a prolonged period to prevent moisture loss, and can be wetted if made of a material suitable for wetting. If the forms are removed early, the concrete member is moistened and covered with polythene sheets to maintain moisture. For large horizontal concrete surfaces exposed to dry weather, a temporary covering is suspended...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Publisher Correction: Muscle abnormalities in Long COVID.

Nature communications·2025

Same author

Reply: Muscle abnormalities in Long COVID.

Nature communications·2025

Same author

Burden of depressive symptoms and non-alcohol substance abuse; and their association with alcohol use and partner violence: a cross-sectional study in four sub-Saharan Africa countries.

Global mental health (Cambridge, England)·2018

Same author

When is a randomised controlled trial health equity relevant? Development and validation of a conceptual framework.

BMJ open·2017

Same author

Evaluating Cinchona bark and quinine for treating and preventing malaria.

Journal of the Royal Society of Medicine·2017

Same author

Evaluating Cinchona bark and quinine for treating and preventing malaria.

Journal of the Royal Society of Medicine·2017

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Video

Updated: Jul 5, 2026

A Preliminary Study on Warm Acupuncture and Moxibustion for Treating Chronic Obstructive Pulmonary Disease with Abdominal Distension

A Preliminary Study on Warm Acupuncture and Moxibustion for Treating Chronic Obstructive Pulmonary Disease with Abdominal Distension

Published on: September 1, 2023

Directly observed therapy and treatment adherence.

J Volmink¹, P Matchaba, P Garner

¹South African Cochrane Centre, Medical Research Council, Cape Town, South Africa. jvolmink@mrc.ac.za

Lancet (London, England)

|April 25, 2000

Summary

Direct observation therapy (DOT) for tuberculosis treatment involves more than just watching patients. Successful DOT programs utilize multiple components beyond direct observation to improve medication adherence.

More Related Videos

Acupoint Catgut Embedding Therapy in Traditional Chinese Medicine for Managing Allergic Rhinitis

Acupoint Catgut Embedding Therapy in Traditional Chinese Medicine for Managing Allergic Rhinitis

Published on: December 20, 2024

A New Technique for Treating Low-risk Prostate Cancer—Super Active Surveillance

A New Technique for Treating Low-risk Prostate Cancer—Super Active Surveillance

Published on: November 7, 2025

Related Experiment Videos

Last Updated: Jul 5, 2026

A Preliminary Study on Warm Acupuncture and Moxibustion for Treating Chronic Obstructive Pulmonary Disease with Abdominal Distension

A Preliminary Study on Warm Acupuncture and Moxibustion for Treating Chronic Obstructive Pulmonary Disease with Abdominal Distension

Published on: September 1, 2023

Acupoint Catgut Embedding Therapy in Traditional Chinese Medicine for Managing Allergic Rhinitis

Acupoint Catgut Embedding Therapy in Traditional Chinese Medicine for Managing Allergic Rhinitis

Published on: December 20, 2024

A New Technique for Treating Low-risk Prostate Cancer—Super Active Surveillance

A New Technique for Treating Low-risk Prostate Cancer—Super Active Surveillance

Published on: November 7, 2025

Area of Science:

Public Health
Infectious Disease Management
Health Services Research

Background:

Direct observation of patients taking medication is a strategy to improve tuberculosis treatment completion rates.
Implementing direct observation therapy (DOT) programs involves a complex array of interventions influencing patient adherence.
Policymakers require a clear understanding of these multifaceted inputs for successful program implementation.

Purpose of the Study:

To systematically identify and review published reports of direct observation therapy (DOT) programs.
To compare the inputs of various DOT programs with the World Health Organization's (WHO) short-course DOT strategy.
To clarify the components contributing to the success of DOT programs.

Main Methods:

Systematic literature review of published reports on DOT programs.
Comparative analysis of identified DOT program inputs against WHO's DOT strategy.
Qualitative synthesis of program components and their potential impact on adherence.

Main Results:

DOT programs often incorporate more than the five core elements of the WHO strategy.
Commonly included additional components include incentives, defaulter tracing, legal sanctions, patient-centered approaches, staff motivation, supervision, and external funding.
The success of DOT programs appears to be influenced by a combination of multiple components, not solely direct observation.

Conclusions:

Direct observation alone may be an insufficient focus for improving tuberculosis treatment adherence.
The success of DOT programs is likely attributable to a complex interplay of various programmatic inputs.
The WHO should explicitly detail the multiple components contributing to successful DOT programs to guide policymakers and practitioners.