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Related Experiment Videos

The vasomotor centre and its afferent pathways.

M D Joy

    Clinical Science and Molecular Medicine. Supplement
    |June 1, 1975
    PubMed
    Summary

    The area postrema is not essential for cardiovascular responses to carotid occlusion in greyhounds. These responses, along with those to angiotensin II, do not require brain connections above the pons.

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    Area of Science:

    • Neuroscience
    • Cardiovascular Physiology

    Background:

    • The area postrema plays a role in cardiovascular regulation.
    • The precise location and neural pathways of cardiovascular reflexes are not fully understood.

    Purpose of the Study:

    • To investigate the role of the area postrema in cardiovascular responses to angiotensin II and carotid occlusion.
    • To determine the necessity of brainstem connections above the pons for these responses.

    Main Methods:

    • Experiments were conducted on two groups of anesthetized greyhounds.
    • Procedures included bilateral area postrema ablation and mid-collicular transection.
    • Cardiovascular responses to vertebral artery infusion of angiotensin II and bilateral carotid artery occlusion were measured.

    Main Results:

    • Bilateral area postrema ablation abolished the response to angiotensin II but not to carotid occlusion.
    • Mid-collicular transection did not abolish responses to either stimulus.
    • Carotid occlusion responses were not significantly altered by area postrema ablation.

    Conclusions:

    • Cardiovascular response pathways to carotid occlusion are anatomically distinct from the area postrema.
    • Neither the angiotensin II nor the carotid occlusion response requires neural connections superior to the pons.

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