Methodology in epidemiological studies of human neurobehavioral toxicity: a case study with critical review

Health care professionals and government decision makers concerned with neurotoxicity increasingly rely on neuropsychological research studies. An example is an article relied upon by the U.S. Environmental Protection Agency that reported effects on neurobehavioral performance in a group of factory workers exposed to toluene by Foo, Jeyaratnam, and Koh in 1990, which is described as lacking reliability and as having implausible contents. A critical review can serve as an educational tool for neuropsychologists, to emphasize the need to design and document their research and interpret findings without speculation. For example, in the Foo, et al. study the implications of the findings for the general population cannot be interpreted. To conclude that this study has identified toluene as the cause of neurobehavioral deficits is a leap of inference far exceeding the power in their study. The review underscores the need for more critical reviews of research relied upon by decision makers and researchers.