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Serum vitamin E levels in patients of chronic myeloid leukaemia
P S Ghalaut1, V Singh, S Gupta
1Dept of Medicine (Unit-VI) and Haematology, Pt BD Sharma Post Graduate Institute of Medical Sciences, Rohtak.
Objective:
To estimate vitamin E levels in sera of patients of chronic myeloid leukaemia (CML) before and after treatment with busulphan and hydroxyurea and to compare the levels with those in healthy controls.
Methods:
The study was carried out in a total of 50 subjects (mean age 34 +/- 8.86 years; 25 were proved cases of CML and 25 were healthy controls. Vitamin E level was measured by spectrofluorometeric method. In patients of CML vitamin E level was estimated twice i.e. once when their total leucocyte count (TLC) was raised (i.e. before treatment) and then after treatment after bringing the TLC near normal.
Results:
The mean serum vitamin E level in 25 normal healthy controls was 7.19 micrograms/ml and that in 25 patients of CML at presentation (before treatment) was 2.67 micrograms/ml. It increased to 3.61 micrograms/ml after treatment.
Conclusion:
The results show that patients of CML have a significantly lower (p < 0.001) level of serum vitamin E as compared to normal healthy adults and that the level of vitamin E increased significantly (p < 0.001) after treatment even without supplementing vitamin E.