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Updated: Oct 16, 2026

Implantation of an Isoproterenol Mini-Pump to Induce Heart Failure in Mice
Published on: October 3, 2019
Beta-adrenoceptor inhibition for induction of acute cardiac failure in pigs
T Petzold1, P Feindt, M D Menger
1Department of Thoracic and Cardiovascular Surgery, Heinrich-Heine-Universität Düsseldorf, Germany.
Abstract:
For the testing of heart assist devices most animal models of acute cardiac failure that are usually used show certain disadvantages. We therefore developed a new method using the beta-adrenoceptor antagonist carazolol. We administered a bolus injection of 1 mg/kg followed by a continuous infusion of 1 mg/kg/h in adult German 'Landrasse' pigs. Blood pressure, heart rate, cardiac output and maximum left ventricular pressure rise time showed a significant (P < 0.05) reduction of the control value varying between 40% and 59%. The method is suitable for the testing of surgical approaches in heart failure.
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