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Updated: Aug 18, 2026

The Measurement and Treatment of Suppression in Amblyopia
Published on: December 14, 2012
Abnormal function of the parvocellular visual system in anisometropic amblyopia
Y Shan1, M L Moster, R A Roemer
1Department of Neurosensory Sciences, Albert Einstein Medical Center, Temple University, Philadelphia, PA 19141, USA.
Purpose:
To study the function of the parvocellular (P) and the magnocellular (M) visual systems with steady-state visual evoked potentials (VEPs) in anisometropic amblyopes.
Methods:
A matrix of isolated checks was superimposed on a steady background with different check sizes and temporal frequencies to form specific stimuli to preferentially activate the P or the M visual system. The amplitude of the VEP fundamental frequency was analyzed at the electrode Oz of 5 anisometropic amblyopes and 22 normal subjects. The normal subjects were tested at two visual acuity (VA) levels, 20/20 and 20/40, modified by lenses, to match with the VA levels of the fellow eyes and the amblyopic eyes of the amblyopes, respectively.
Results:
No significant amplitude difference was found between the dominant eyes and nondominant eyes of the normal subjects for either P or M stimuli at both 20/20 and 20/40 VA levels (P>.05). No significant amplitude difference was found between the fellow eyes of the amblyopes and the dominant eyes of normals for either P or M stimuli at 20/20 VA level (P>.05). A significant amplitude difference was found between the amblyopic eyes and the nondominant eyes of the normals for P stimuli (P<.05) but not for M stimuli (P>.05) at 20/40 VA level.
Conclusions:
The amplitude of the VEP fundamental frequency was selectively reduced for P stimuli in anisometropic amblyopic eyes. This clinical electrophysiologic finding confirms that only the function of the P visual system is abnormal in anisometropic amblyopic eyes.
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