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Related Experiment Video

Updated: Jun 30, 2026

Strategic Endothelial Cell Tube Formation Assay: Comparing Extracellular Matrix and Growth Factor Reduced Extracellular Matrix

Strategic Endothelial Cell Tube Formation Assay: Comparing Extracellular Matrix and Growth Factor Reduced Extracellular Matrix

Published on: August 14, 2016

Basic fibroblast growth factor increases tissue factor expression in circulating monocytes and in vascular wall.

D Corseaux¹, T Meurice, I Six

¹Laboratoire d'Hématologie, Centre Hospitalier Régional Universitaire and Faculté de Médecine, Lille, France.

|April 26, 2000

Summary

Basic fibroblast growth factor (bFGF) increases tissue factor (TF) expression in monocytes and vascular cells in rabbits. This effect is notable in normal rabbits and less pronounced in hypercholesterolemic ones, requiring further investigation into thrombosis risk.

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Area of Science:

Vascular Biology
Hemostasis
Endocrinology

Background:

Basic fibroblast growth factor (bFGF) is known to promote vascular repair and angiogenesis.
bFGF can induce tissue factor (TF) in vitro, a key initiator of thrombogenesis.
The role of bFGF-induced TF in angiogenesis warrants investigation.

Purpose of the Study:

To investigate whether systemic bFGF administration induces TF expression in monocytes and vascular cells.
To compare TF expression in normal and hypercholesterolemic rabbits following bFGF administration.

Main Methods:

TF expression was studied in normal and cholesterol-fed rabbits.
Animals received intravenous bFGF or saline injections.
TF expression in monocytes and aortic sections was assessed via immunohistochemistry.

Main Results:

bFGF administration significantly increased monocyte TF expression in both normal and hypercholesterolemic rabbits.
TF expression was lower in hypercholesterolemic rabbits compared to normal rabbits.
bFGF induced strong TF expression in the vascular wall of normal rabbits and weak expression in hypercholesterolemic rabbits.

Conclusions:

Systemic bFGF administration markedly increases TF expression in circulating monocytes and the vascular wall.
The effect of bFGF on TF expression is more pronounced in normal rabbits than in hypercholesterolemic rabbits.
The clinical significance of bFGF-induced TF expression regarding in vivo thrombosis requires further study.