Related Experiment Videos
An efficient method for the synthesis of [2-(15)N]guanosine and 2'-deoxy[2-(15)N]guanosine derivatives
K Kamaike1, K Kinoshita, K Niwa
1Laboratory of Pharmaceutical Chemistry, School of Pharmacy, Tokyo University of Pharmacy and Life Science, Japan.
Nucleic Acids Symposium Series
|April 26, 2000
Abstract:
Nucleophilic substitution reaction of 6-chloro-2-fluoro-9-beta-D-ribofuranosyl-9H-purine derivative, prepared from guanosine, with potassium [15N]phthalimide at 40 degrees C for 9 h in DMF, followed by hydrolysis, afforded [2-(15)N]guanosine derivative efficiently. The corresponding 2'-deoxy derivative was also synthesized through a similar procedure.