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Related Experiment Videos

Pepsin and the esophagus.

B I Hirschowitz1

  • 1Division of Gastroenterology and Hepatology, University of Alabama at Birmingham, 35294-0007, USA. bhirschowitz@gihep.uab.edu

The Yale Journal of Biology and Medicine
|April 26, 2000
PubMed
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Pepsin in gastric acid causes significant esophageal damage, especially at lower pH levels. Non-steroidal anti-inflammatory drugs can worsen this esophagitis.

Area of Science:

  • Gastroenterology
  • Esophageal Pathophysiology

Background:

  • Esophagitis is linked to ineffective lower esophageal sphincter function and excessive gastric acid exposure.
  • The role of pepsin in esophageal mucosal damage requires further investigation.

Purpose of the Study:

  • To investigate the direct role of pepsin in causing esophagitis.
  • To determine the effects of acid and pepsin, alone and in combination, on esophageal mucosa.

Main Methods:

  • Experimental models of esophagitis were used.
  • The esophagus was perfused with acid and/or pepsin under various conditions.
  • The effects of non-steroidal anti-inflammatory drugs (NSAIDs) were also examined.

Main Results:

  • Acid perfusion alone (pH 1.3+) did not cause esophagitis.

Related Experiment Videos

  • Pepsin added to acid (pH 1-3.5) caused significant acute esophageal damage.
  • Pepsin above pH 3.5 did not cause damage.
  • NSAIDs exacerbated damage caused by acidified pepsin.

    • Conclusions:

    • Pepsin plays a critical role in acid-induced esophagitis within its proteolytic pH range.
    • Esophageal mucosal integrity is crucial and can be compromised by NSAIDs.