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Related Experiment Videos

Citrate storage affects Thrombelastograph analysis.

V Camenzind1, T Bombeli, B Seifert

  • 1Institute of Anesthesiology, University Hospital, Zürich, Switzerland.

Anesthesiology
|April 26, 2000
PubMed
Summary
This summary is machine-generated.

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For reliable thrombelastograph analysis (TEG), native blood is best. If immediate processing is impossible, citrated blood can be used if recalcified within 1 to 8 hours for accurate coagulation assessment.

Area of Science:

  • Hematology
  • Clinical Pathology

Background:

  • Thrombelastograph (TEG) analysis is crucial for evaluating blood coagulation.
  • Ideally, whole blood samples are processed immediately for TEG.
  • When immediate processing is not feasible, blood can be citrated and recalcified, but its impact on TEG parameters is not well-documented.

Purpose of the Study:

  • To investigate the effects of citrate storage and subsequent recalcification on thromboelastograph (TEG) parameters.
  • To determine the optimal timeframe for assessing TEG in citrated and recalcified blood samples.

Main Methods:

  • Three studies involving 90 surgical patients were conducted.
  • TEG was performed on native blood and citrated blood (stored for 0-30 minutes) after recalcification.
  • Further studies assessed TEG parameters in citrated blood recalcified after 1-72 hours of storage.

Related Experiment Videos

  • Biomarkers of thrombin activation and platelet release were measured.

    • Main Results:

    • TEG parameters differed significantly between native and recalcified citrated blood.
    • Parameters changed significantly with 30-minute and 72-hour citrate storage.
    • TEG parameters remained stable for citrated blood stored and recalcified between 1 and 8 hours.
    • Evidence of gradual thrombin activation and increased platelet release markers was observed during citrate storage.

    Conclusions:

    • Analysis of native blood provides the most accurate TEG results.
    • Citrated blood can be utilized for TEG analysis if recalcified within 1 to 8 hours post-collection when immediate processing is not possible.