Related Experiment Videos
Adapter proteins in lymphocyte antigen-receptor signaling
P S Myung1, N J Boerthe, G A Koretzky
1Graduate Program of Immunology, University of Pennsylvania, The Leonard and Madlyn Abramson Family Cancer Research Institute, Philadelphia, PA 19104-6160, USA.
Current Opinion in Immunology
|April 27, 2000
Abstract:
Adapter molecules contain discrete modular domains that direct specific intermolecular interactions to orchestrate assembly of signaling complexes. A number of adapter proteins play critical roles in both positive and negative regulation of antigen-receptor signaling, influencing lymphocyte development and function.