Jove
Visualize
Contact Us

Related Experiment Videos

Epstein-barr virus-associated malignancies: epidemiologic patterns and etiologic implications.

J L Hsu1, S L Glaser

  • 1Northern California Cancer Center, 32960 Alvarado-Niles Road, Suite 600, Union City, CA 94587, USA.

Critical Reviews in Oncology/Hematology
|April 27, 2000
PubMed
Summary

Epstein-Barr virus (EBV) is linked to various cancers. This review connects EBV

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

EZH2 contributes to the response to PARP inhibitors through its PARP-mediated poly-ADP ribosylation in breast cancer.

Oncogene·2017
Same author

Aspergillus-related pulmonary diseases in lung transplantation.

Medical mycology·2016
Same author

Targeted complement inhibition and microvasculature in transplants: a therapeutic perspective.

Clinical and experimental immunology·2015
Same author

A meta-analysis of Hodgkin lymphoma reveals 19p13.3 TCF3 as a novel susceptibility locus.

Nature communications·2014
Same author

Hodgkin lymphoma incidence in California Hispanics: influence of nativity and tumor Epstein-Barr virus.

Cancer causes & control : CCC·2014
Same author

Response to Evens et al., racial disparities in Hodgkin's lymphoma: a comprehensive population-based analysis, Annals of Oncology 23: 2128-2137, 2012.

Annals of oncology : official journal of the European Society for Medical Oncology·2013
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Area of Science:

  • Oncology
  • Virology
  • Epidemiology

Background:

  • Epstein-Barr virus (EBV), a herpesvirus, infects B-lymphocytes.
  • EBV is associated with a diverse range of malignancies, including lymphomas and carcinomas.
  • The epidemiological patterns of EBV-associated cancers have not been comprehensively analyzed together.

Purpose of the Study:

  • To correlate incidence patterns and risk factors of EBV-related cancers.
  • To elucidate the role of EBV in carcinogenesis through virus-host interactions.
  • To provide a biological context for understanding EBV-driven cancer development.

Main Methods:

  • Review of EBV virology and primary infection.
  • Summarization of epidemiological features for each associated malignancy.

Related Experiment Videos

  • Synthesis of epidemiologic data by risk factors.
  • Formulation of hypotheses on etiologic mechanisms.

    • Main Results:

    • EBV is implicated in Burkitt's lymphoma, Hodgkin's disease, nasopharyngeal carcinoma, and others.
    • Commonalities and contrasts in risk factors across EBV-related cancers were identified.
    • Potential mechanisms linking risk factors to viral life cycle stages were proposed.

    Conclusions:

    • Understanding EBV's role in carcinogenesis requires integrating epidemiological and virological data.
    • Further research into virus-host interactions can illuminate EBV-related cancer etiology.
    • This review provides a framework for investigating EBV's contribution to diverse malignancies.