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Published on: December 21, 2011
A central role for the endothelial NADPH oxidase in atherosclerosis
1Department of Molecular Genetics, Biochemistry and Microbiology, University of Cincinnati, 231 Bethesda Avenue, P.O. Box 670524, Cincinnati, OH 45267-0524, USA.
Abstract:
An increasing body of evidence has demonstrated that NADPH oxidase plays a critical role in several early steps leading toward the development of atherosclerosis. These effects appear to be carried out by both the ability of O2- to act as a small second messenger molecule, and potentially the oxidation of low density lipoprotein by O2-. We describe a model for the initiation and development of atherosclerosis that suggests targeted inhibition of NADPH oxidase as a powerful site for prevention and treatment of this disease.
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