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Cardiac opioids.

B A Barron1

  • 1Department of Integrative Physiology, Cardiovascular Research Institute, University of North Texas Health Science Center, Fort Worth, Texas 76107, USA. barronb@hsc.unt.edu

Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.)
|April 27, 2000
PubMed
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Opioid peptides like endorphins are found in heart tissue, suggesting roles beyond the nervous system. This review explores their cardiac distribution, biochemistry, and function.

Area of Science:

  • Cardiovascular Science
  • Neuroendocrinology
  • Molecular Biology

Background:

  • Opioid peptides traditionally viewed as neuropeptides or neurotransmitters.
  • Recent findings indicate opioid peptides in non-neuronal tissues.
  • This suggests potential autocrine, paracrine, or endocrine roles.

Purpose of the Study:

  • To review the current literature on opioid peptides in cardiac tissue.
  • To examine the cardiac distribution, biochemistry, and function of these peptides.

Main Methods:

  • Literature review of recent scientific publications.
  • Analysis of studies focusing on opioid peptides in cardiac myocytes and heart tissue.

Main Results:

  • Opioid peptides, including enkephalins, dynorphins, and endorphins, have been identified in isolated cardiac myocytes.

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  • Evidence supports the presence of these peptides within heart tissue.

    • Conclusions:

    • Opioid peptides may exert autocrine, paracrine, or endocrine functions within the cardiovascular system.
    • Further research is warranted to fully elucidate the cardiac roles of opioid peptides.