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Updated: Aug 4, 2026

Assaying Proteasomal Degradation in a Cell-free System in Plants
Published on: March 27, 2014
AAA proteases: cellular machines for degrading membrane proteins
1Adolf-Butenandt-Institut für Physiologische Chemie, Ludwig-Maximilians-Universität München, Goethestrasse 33, 80336 München, Germany. langer@bio.med.uni-muenchen.de
Abstract:
AAA proteases are a conserved class of ATP-dependent proteases that mediate the degradation of membrane proteins in bacteria, mitochondria and chloroplasts. They combine proteolytic and chaperone-like activities and thus form a membrane-integrated quality-control system. Inactivation of AAA proteases causes severe defects in various organisms, including neurodegeneration in humans. Proteolysis by AAA proteases is modulated by another membrane-protein complex that is composed of prohibitins in eukaryotic cells and related proteins in bacteria.
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