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Disoxaril-related 3-(diethylamino)-5-phenylisoxazoles
1Department of Pharmaceutical Sciences, University of Genova, Italy. mazzei@ermes.cba.unige.it
Farmaco (Societa Chimica Italiana : 1989)
|April 27, 2000
Abstract:
Previous research has shown that 3-(dialkylamino)-5-phenylisoxazoles possessing a compact structure were active against HRV-2 and, consequently, presented a type B activity. In this paper, 3-(diethylamino)-5-phenylisoxazoles, which are structurally more elongated and related to Disoxaril, were synthesized in view to attempt type A activity against HRV-14. Unfortunately, all tested compounds were devoid of activity against HRV-14 (and HIV-1) or exhibited great toxicity.