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The abasic site as a target for generation of locally multiply damaged sites
A Martelli1, N Berthet, J F Constant
1LEDSS, Chimie Bioorganique, UMR CNRS 5616, Université Joseph Fourier, Grenoble, France.
Bioorganic & Medicinal Chemistry Letters
|April 27, 2000
Abstract:
Abasic sites in DNA have been specifically targeted by synthetic compounds able to cleave DNA at abasic sites and to induce photodamages in the vicinity of the lesion. The synthesis and the photoactivity of the drugs on abasic sites containing DNA and oligonucleotides are reported.