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Related Experiment Videos

Progesterone receptor expression in orbital cavernous hemangiomas.

L Di Tommaso1, F Scarpellini, F Salvi

  • 1Department of Oncology, Ospedale Bellaria, University of Bologna, Italy.

Virchows Archiv : an International Journal of Pathology
|April 27, 2000
PubMed
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Orbital cavernous hemangiomas (OCH) show smooth muscle markers and progesterone receptors, similar to angioleiomyomas. This suggests OCH are mesenchymal lesions influenced by sex hormones.

Area of Science:

  • Ophthalmology
  • Pathology
  • Oncology

Background:

  • Orbital cavernous hemangiomas (OCH) exhibit cellular vascular walls with smooth muscle characteristics.
  • Hormonal influences can alter the presentation of vascular neoplasms.

Purpose of the Study:

  • To investigate smooth muscle markers and sex steroid receptors in OCH.
  • To compare OCH with cutaneous hemangiomas and subcutaneous angioleiomyomas.

Main Methods:

  • Immunohistochemical analysis of 12 OCH cases for smooth muscle actin (SMA), desmin, progesterone receptor (PR), and estrogen receptor (ER).
  • Comparison with 10 cutaneous hemangiomas and 10 subcutaneous angioleiomyomas.

Main Results:

  • All OCH cases showed positivity for SMA and desmin in vascular smooth muscle cells.

Related Experiment Videos

  • OCH demonstrated PR positivity in smooth muscle and endothelial cells.
  • PR was found in 60% of angioleiomyomas but not in cutaneous hemangiomas; ER was negative in all tested cases.

    • Conclusions:

    • Orbital cavernous hemangiomas share morphological and immunohistochemical similarities with subcutaneous angioleiomyomas.
    • The presence of PR in OCH indicates they are mesenchymal lesions responsive to sex steroid hormones.