Related Experiment Video
Updated: Aug 2, 2026

Osteopathic Manipulative Treatment as a Useful Adjunctive Tool for Pneumonia
Published on: May 6, 2014
Management of otitis media: 2000 and beyond
1Maxwell Finland Laboratory for Infectious Diseases, Boston Medical Center, MA 02118, USA. jerome.klein@bmc.org
Background:
In the next few years what will alter our modes of diagnosis, choice of therapies and strategies for prevention of acute otitis media (AOM)? These issues, as well as whether antibiotic resistance will continue to threaten the efficacy of currently available antimicrobial agents, whether industry and academia will be able to respond to bacterial resistance with effective new antimicrobial drugs and whether the pneumococcal conjugate vaccine will substantially reduce the incidence of AOM provide a basis for discussing the problems and possible solutions related to AOM. ANTIMICROBIAL DRUGS: Bacteria and viruses will continue to find ways to survive the activity of currently available antimicrobial drugs. Among the new antibacterial drugs under consideration are ketolides, oxazolodinones and quinolones. Guidelines stress limiting usage of antimicrobial agents to diseases that are likely caused by bacterial pathogens. Antiviral drugs are now available against influenza virus and respiratory syncytial virus infections.
Diagnosis:
Tympanometry and/or acoustic reflectometry are adjunctive techniques for assisting in the diagnosis of middle ear effusion in children whose otoscopic examination is ambiguous. Laser myringotomy has been used in several hundred children; however, there are no published studies of randomized trials. NEW VACCINES: Investigators have evaluated the safety and efficacy of a heptavalent pneumococcal polysaccharide vaccine conjugated with CRM197 (a diphtheria toxin mutant). The results showed a reduction in the overall burden of severe and recurrent AOM. Respiratory syncytial virus is the viral pathogen most frequently associated with AOM. For this reason safe and effective viral vaccines are needed to complement the efficacy of bacterial vaccines for prevention of AOM.
Conclusions:
Parents influence decisions by pediatricians to use antimicrobial agents and should be informed about the appropriate usage of antibiotics. Educators and public health officials must find techniques to distinguish WebSites that provide information of value from those that are not credible. Of paramount importance is the development of techniques to increase the accuracy of clinical and microbiologic diagnosis. Finally there is a need for studies of appropriate scientific design that can assess the efficacy and safety of alternative therapies.
Insights
New strategies are needed to combat acute otitis media (AOM), addressing antibiotic resistance and improving diagnostic accuracy. Developing novel antimicrobial drugs and vaccines is crucial for effective AOM prevention and treatment.
Area of Science:
- Pediatrics
- Infectious Diseases
- Microbiology
Background:
- Antibiotic resistance poses a significant threat to the efficacy of current antimicrobial agents for acute otitis media (AOM).
- The development of new antimicrobial drugs and vaccines is essential to address evolving bacterial resistance and reduce AOM incidence.
- Viral pathogens, particularly respiratory syncytial virus, are frequently associated with AOM, highlighting the need for effective antiviral strategies.
Purpose of the Study:
- To discuss current problems and potential solutions for acute otitis media (AOM).
- To explore the impact of antibiotic resistance on AOM treatment and prevention.
- To evaluate the role of new vaccines and diagnostic techniques in managing AOM.
Main Methods:
- Adjunctive diagnostic techniques like tympanometry and acoustic reflectometry aid in identifying middle ear effusion.
- Evaluation of a heptavalent pneumococcal polysaccharide vaccine demonstrated a reduction in severe and recurrent AOM.
- Laser myringotomy has been used, but randomized trials are lacking.
Main Results:
- The pneumococcal conjugate vaccine showed a reduction in the overall burden of severe and recurrent AOM.
- New antibacterial drug classes, including ketolides, oxazolodinones, and quinolones, are under consideration.
- Antiviral drugs are available for influenza and respiratory syncytial virus infections.
Conclusions:
- Parental influence on antibiotic prescribing necessitates education on appropriate usage.
- Accurate clinical and microbiologic diagnosis is paramount for effective AOM management.
- Further research with rigorous scientific design is needed to assess alternative therapies for AOM.
Related Concept Videos
Tonsillitis I: Introduction
Etiology
Three primary contributing factors have been identified.
Tonsillitis II: Management
Pneumonia IV: Management
Bacterial Pneumonia Treatment
For bacterial pneumonia, antibiotics serve as the cornerstone of therapy. Initial treatment often begins with empirical antibiotics, tailored to the anticipated causative organism and adjusted based on culture results. Key antibiotic choices include:
Pneumonia V: Nursing management and Prevention
The nurse must practice strict medical asepsis and adhere to infection control guidelines to minimize healthcare-associated infections.
Enhance airway patency
Position the patient correctly to facilitate drainage of the affected lung segments. Manual or mechanical percussion and vibration can also be employed.
Chronic Obstructive Pulmonary Disease-V: Management
Smoking Cessation
Mitral Stenosis III: Medical Management

