Clinical characteristics of patients with fresh left ventricular thrombus

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K Iga1, H Kondo, T Tamura

  • 1Department of Cardiology, Tenri Hospital, Japan. igakan@kcn.ne.jp

Japanese Circulation Journal
|April 27, 2000
PubMed

Insights

Fresh left ventricular thrombus (LVT) in severe heart failure patients may develop after diuretic therapy. Early anticoagulant therapy is recommended to resolve LVT and prevent complications.

Area of Science:

  • Cardiology
  • Internal Medicine

Background:

  • Left ventricular thrombus (LVT) is a serious complication in patients with severe congestive heart failure.
  • Left ventricular systolic dysfunction is a common finding in these patients.

Purpose of the Study:

  • To analyze the clinical characteristics of patients with fresh left ventricular thrombus (LVT).
  • To investigate the relationship between diuretic therapy and LVT formation in heart failure patients.

Main Methods:

  • Retrospective analysis of 9 patients with LVT detected via echocardiography over 5 years.
  • Exclusion of patients with acute myocardial infarction.
  • Echocardiography performed before and after furosemide therapy in some patients.

Main Results:

  • All patients exhibited impaired left ventricular systolic function (mean ejection fraction 33%).
  • LVT was detected shortly after furosemide therapy in 7 out of 9 patients with severe congestive heart failure.
  • LVT resolved in 7 patients within 6 months of anticoagulant therapy without thromboembolic events.

Conclusions:

  • Fresh LVT can develop in severe congestive heart failure patients with systolic dysfunction, potentially linked to diuretic therapy.
  • Anticoagulant therapy is recommended for LVT in this patient population to prevent thromboembolic complications.

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