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Related Concept Videos

Cancer Prevention02:59

Cancer Prevention

Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
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In vitro Organoid Culture of Primary Mouse Colon Tumors
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Plant phenolics decrease intestinal tumors in an animal model of familial adenomatous polyposis.

N N Mahmoud1, A M Carothers, D Grunberger

  • 1The New York Hospital-Cornell Medical Center, 525 East 68th Street, New York, NY 10021, USA.

Carcinogenesis
|April 28, 2000
PubMed
Summary

Plant-derived compounds caffeic acid phenethyl ester (CAPE) and curcumin show promise in preventing colon cancer by reducing tumor formation in mice. These natural compounds may inhibit key stages of carcinogenesis.

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Area of Science:

  • Oncology
  • Nutritional Science
  • Molecular Biology

Background:

  • Epidemiological studies link fruit and vegetable consumption to reduced human cancer risk.
  • Plant-derived phenolic compounds exhibit beneficial effects and may inhibit carcinogenesis.
  • Intestinal adenomas can be studied in C57BL/6J-Min/+ mice with an Apc gene mutation.

Purpose of the Study:

  • To investigate the efficacy of plant-derived phenolics (CAPE, curcumin, quercetin, rutin) in preventing intestinal tumors.
  • To assess the impact of these compounds on Apc-associated intestinal carcinogenesis in vivo.
  • To explore the molecular mechanisms underlying tumor prevention by these phenolics.

Main Methods:

  • Administration of CAPE, curcumin, quercetin, and rutin to Min/+ mice at specific dietary levels.
  • Quantification of intestinal tumor formation in treated and control Min/+ mice.
  • Analysis of intestinal tissue for enterocyte apoptosis, proliferation, and beta-catenin expression.

Main Results:

  • CAPE (0.15% diet) reduced tumor formation by 63%; curcumin showed similar inhibition.
  • Quercetin and rutin (2% diet) did not significantly alter tumor formation.
  • Tumor prevention by CAPE and curcumin correlated with increased enterocyte apoptosis and proliferation.
  • CAPE and curcumin decreased oncoprotein beta-catenin expression in enterocytes.

Conclusions:

  • CAPE and curcumin are effective in suppressing Apc-associated intestinal carcinogenesis in mice.
  • These plant phenolics demonstrate potential as chemopreventive agents against colon cancer.
  • The antitumor effects are linked to modulation of apoptosis, proliferation, and beta-catenin signaling.