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Related Experiment Videos

Learning-specific decrease in synaptosomal ATP diphosphohydrolase activity from hippocampus and entorhinal cortex of

C D Bonan1, R Roesler, G S Pereira

  • 1Departamento de Bioquímica, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.

Brain Research
|April 28, 2000
PubMed
Summary

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Extracellular adenosine triphosphate (ATP) plays a role in memory formation. Inhibitory avoidance training decreased ATP diphosphohydrolase activity in rat hippocampus and entorhinal cortex, suggesting its involvement in memory.

Area of Science:

  • Neuroscience
  • Biochemistry

Background:

  • Extracellular adenosine triphosphate (ATP) is implicated in memory formation.
  • Ectonucleotidases, including ATP diphosphohydrolase, modulate extracellular ATP levels.

Purpose of the Study:

  • To investigate the effect of inhibitory avoidance training on ectonucleotidase activities in specific brain regions.
  • To determine the role of ATP diphosphohydrolase in inhibitory avoidance memory formation.

Main Methods:

  • Inhibitory avoidance training was performed on rats.
  • Ectonucleotidase activities, specifically ATP diphosphohydrolase, were measured in synaptosomes from the hippocampus, entorhinal cortex, and parietal cortex at different time points after training.

Main Results:

  • A significant decrease (33%) in hippocampal ATP diphosphohydrolase activity was observed 180 minutes after training.

Related Experiment Videos

  • Immediately after training, synaptosomal ATP diphosphohydrolase activity decreased by 30% for ATP and 42% for ADP in the entorhinal cortex.

    • Conclusions:

    • The findings suggest that ATP diphosphohydrolase in the hippocampus and entorhinal cortex plays an integrated role in the formation of inhibitory avoidance memory.
    • Modulation of extracellular ATP levels by ATP diphosphohydrolase is crucial for memory consolidation.