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Inhibition of DNA topoisomerases by nidulalin A derivatives
1Pharmaceutical Research Laboratories, Ajinomoto Co., Inc., Kawasaki, Japan.
Biological & Pharmaceutical Bulletin
|April 28, 2000
Abstract:
Three cytotoxic dihydroxanthone derivatives, nidulalin A(1), F390B(2), and F390C(3) were evaluated for inhibitory activity against DNA topoisomerases. Compounds 1 and 2 inhibited DNA topoisomerase II with IC50 values of 2.2 microM and 16 microM, and 3 inhibited DNA topoisomerase I with an IC50 value of 5.9 microM.