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Related Experiment Videos

Granular cell tumors: a new clinically important histologic finding.

A M Althausen1, D P Kowalski, M E Ludwig

  • 1Women's Ambulatory Health Services, Hartford Hospital, 80 Seymour Street, Hartford, Connecticut 06102-5037, USA.

Gynecologic Oncology
|April 29, 2000
PubMed
Summary

Vulvar granular cell tumors with an infiltrative growth pattern at the advancing edge are more likely to recur, even with negative surgical margins. Reexcision may be recommended for these infiltrative lesions.

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Area of Science:

  • Gynecologic Oncology
  • Surgical Pathology
  • Dermatopathology

Background:

  • Granular cell tumors (GCTs) are rare neoplasms.
  • Vulvar GCTs are the most common variant in the female genital tract.

Purpose of the Study:

  • To review clinical characteristics, histological findings, and surgical treatment of vulvar GCTs.
  • To identify histologic features associated with tumor recurrence.

Main Methods:

  • Retrospective case review of 13 patients with vulvar GCTs.
  • Analysis of tumor growth patterns (nodular vs. infiltrative) and advancing edge characteristics (pushing vs. infiltrative).

Main Results:

  • Eight of 13 tumors exhibited an infiltrative advancing edge; five of these recurred.

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  • Three of the recurrent infiltrative tumors had negative surgical margins.
  • None of the five tumors with a pushing border recurred.

    • Conclusions:

    • An infiltrative growth pattern at the advancing edge of vulvar GCTs is associated with a higher recurrence risk.
    • Reexcision of lesions with infiltrative borders may be a more appropriate management strategy than observation alone.