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Updated: Aug 13, 2026
A Murine Model of Stent Implantation in the Carotid Artery for the Study of Restenosis
Published on: May 14, 2013
Intracoronary Stenting for Restenosis: Long-Term Follow-up: A Single Center Experience
1Division de Cardiologie, Centre Hospitalier Universitaire Vaudois, Rue du Bugnon, 1011, Lausanne, Switzerland.
Insights
Coronary artery stenting effectively treats restenosis after angioplasty in native arteries and venous grafts. This strategy shows good long-term outcomes, with high event-free survival and survival rates.
Area of Science:
- Cardiovascular Medicine
- Interventional Cardiology
- Biomedical Engineering
Background:
- Restenosis following angioplasty is a significant clinical challenge.
- Coronary artery stenting has emerged as a treatment option for restenosis.
- Evaluating the long-term efficacy and safety of coronary stenting is crucial.
Purpose of the Study:
- To assess the long-term outcomes of coronary stent implantation for treating restenosis.
- To evaluate the safety and effectiveness of stenting in native coronary arteries and venous grafts.
Main Methods:
- A cohort of 106 patients received 113 coronary stents (Wallstents, Palmaz-Schatz, Wiktor) for restenosis.
- Stents were implanted in native coronary arteries (86 cases) and venous grafts (20 cases).
- Clinical and angiographic follow-up was conducted at 6 months, and long-term follow-up extended to an estimated 104 months.
Main Results:
- Stent implantation successfully increased minimal lumen diameter in both native arteries and venous grafts.
- At 6 months, clinical events occurred in 20% of patients (including deaths, myocardial infarctions, and re-angioplasty).
- Long-term follow-up (mean 65 months) showed sustained efficacy, with 70% of patients remaining event-free and a 95% survival rate.
Conclusions:
- Coronary stent implantation is a valid and effective strategy for treating restenosis after conventional balloon angioplasty.
- The procedure demonstrates favorable long-term clinical and angiographic results.
- Stenting offers a durable solution for patients with restenosis in both native coronary arteries and venous grafts.
Abstract:
One-hundred thirteen stents (78 Wallstents, 29 Palmaz-Schatz and 6 Wiktor) were implanted in 106 patients aged 63 +/- 5 years to treat a restenosis following previous angioplasty in a native coronary artery (86 cases) and in a venous graft (20 cases). Implantation was technically possible in all cases. The native vessels had a mean reference diameter of 3.3 +/- 0.3 mm and their mean minimal lumen diameter increased from 1.2 +/- 0.3 mm before angioplasty to 2.8 +/- 0.8 after stent implantation. The venous grafts mean reference diameter was 4.4 +/- 0.7 mm and their mean minimal lumen diameter increased from 1.3 +/- 0.4 mm before angioplasty to 4.0 +/- 0.7 mm after implantation. Percentage stenosis in the native arteries and in the venous grafts were respectively 78 +/- 13% and 69 +/- 14% before angioplasty and 24 +/- 8% and 22 +/- 8% after stent implantation. Complications at 6 months, presented as a ranking scale with 100% follow-up rate were, overall, of 20% clinical events (4% deaths, 6% myocardial infractions, 2% coronary artery bypass grafting and 8% re-angioplasty). Angiographic complications were of 8% subacute thrombosis and 19% restenosis and chronic occlusions. Long-term, at 65 +/- 9 months, clinical (86% follow-up) and angiographic (74% follow-up) showed that only a further 9% clinical events and 14% restenosis (12% of them between 6 and 12 months) occurred after 6 months. At an estimated follow-up time of 104 months, 70% patients remain event-free and the survival rate is 95%. In conclusion, stent implantation in the treatment of restenosis following conventional balloon angioplasty is a valid strategy with good long-term results.
