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Vasoactive substances in renal transplantation
D Demetriou1, C Wenter, B Watschinger
1Department of Internal Medicine III, University of Vienna, Austria.
Current Opinion in Urology
|April 29, 2000
Summary
Kidney transplantation involves insults causing damage, influenced by various substances. Targeting vasoactive substances offers potential therapeutic strategies for long-term kidney allograft survival.
Area of Science:
- Nephrology
- Transplantation Immunology
- Vascular Biology
Background:
- Kidney allografts face insults leading to functional and structural damage post-transplantation.
- These insults are modulated by hormones, cytokines, enzymes, and growth factors from graft and infiltrating cells.
Purpose of the Study:
- To review the pathophysiological role of vasoactive substances in kidney transplantation.
- To summarize therapeutic strategies targeting vasoactive substances for improved allograft survival.
Main Methods:
- Literature review of pathophysiological roles of vasoactive substances.
- Summary of recent reports on therapeutic targeting of these substances.
Main Results:
- Vasoactive substances, including vasoconstrictors (angiotensin II, endothelin) and vasodilators (nitric oxide, adrenomedullin, atrial natriuretic peptide), significantly impact kidney allografts.
- Evidence suggests these substances are key mediators of transplant-related injury.
Conclusions:
- Dysregulation of vasoactive substances contributes to kidney transplant dysfunction and damage.
- Targeting vasoactive substances presents a promising therapeutic avenue for enhancing long-term kidney allograft survival.