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Updated: Jul 30, 2026

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Multi-target Chromogenic Whole-mount In Situ Hybridization for Comparing Gene Expression Domains in Drosophila Embryos
Published on: January 31, 2016
Spatio-temporal registration of the expression patterns of Drosophila segmentation genes
E M Myasnikova1, D Kosman, J Reinitz
1Institute of High Performance Computing and Data Bases, St.Petersburg, Russia. reinitz@kruppel.molbio.mssm.edu
Abstract:
The application of image registration techniques resulted in the construction of an integrated atlas of Drosophila segmentation gene expression in both space and time. The registration method was based on a quadratic spline approximation with flexible knots. A classifier for automatic attribution of an embryo to one of the temporal classes according to its gene expression pattern was developed.)

