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Related Experiment Videos

Proteomics: capacity versus utility.

J L Harry1, M R Wilkins, B R Herbert

  • 1Proteome Systems Limited, North Ryde, Sydney, NSW, Australia. jenny.harry@proteomesystems.com

Electrophoresis
|April 29, 2000
PubMed
Summary
This summary is machine-generated.

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High-throughput genomic and proteomic approaches enable global studies of complex biological interactions. This review examines the current capacity and utility of proteome research, highlighting technological advancements and funding focus.

Area of Science:

  • Molecular Biology
  • Systems Biology
  • Biochemistry

Background:

  • Historically, biological research focused on individual genes or proteins.
  • Technological advancements now permit the study of complex interactions within biological systems.
  • Global studies, utilizing genomic and proteomic approaches, are essential for this new era of research.

Purpose of the Study:

  • To review the current state of proteome research.
  • To assess the capacity and utility of high-throughput proteomic methods.
  • To understand the focus of public and private funding bodies on proteomic capabilities.

Main Methods:

  • High-throughput genomic approaches for large-scale data generation.
  • High-throughput proteomic approaches for analyzing protein interactions.

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  • Review of current technological capabilities in proteomics.

    • Main Results:

    • Genomics has progressed through a developmental phase focused on sequence data generation.
    • Proteomics is in a phase of technological development, with high-throughput capacity being a key challenge.
    • Funding is increasingly directed towards the practical utility of high-throughput proteomic capacity.

    Conclusions:

    • High-throughput methods are crucial for studying immense numbers of genes and proteins.
    • The utility and capacity of proteome research are under increasing scrutiny by funding bodies.
    • Advancements in technology are driving the shift towards global biological system studies.