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Cubilin, a high-density lipoprotein receptor.

S K Moestrup¹, R Kozyraki

¹Department of Medical Biochemistry, University of Aarhus, Denmark. skm@biobase.dk

Current Opinion in Lipidology

|April 29, 2000

Summary

High-density lipoprotein (HDL) uptake involves cubilin, a novel receptor in absorptive epithelia. Cubilin facilitates HDL and apolipoprotein AI endocytosis, impacting renal clearance and cholesterol transport.

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Area of Science:

Biochemistry
Cell Biology
Molecular Medicine

Background:

High-density lipoprotein (HDL) metabolism is intricate, involving plasma factors and cellular receptors.
Scavenger receptor BI mediates selective cholesteryl ester uptake, but HDL holoparticle endocytosis also occurs.

Purpose of the Study:

To identify novel receptors involved in HDL endocytosis.
To elucidate the role of cubilin in HDL and apolipoprotein AI uptake.

Main Methods:

Receptor identification and characterization.
Cellular uptake assays using HDL and apolipoprotein AI.

Main Results:

Cubilin was identified as a high-affinity receptor for HDL and lipid-poor apolipoprotein AI endocytosis.
Cubilin is expressed in various absorptive epithelia.

Conclusions:

Cubilin plays a significant role in the renal clearance of apolipoprotein AI/HDL.
Cubilin may be crucial for maternal-fetal cholesterol transport.

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