Transgenic animals with altered high-density lipoprotein composition and functions

Our understanding of HDL metabolism in vivo has greatly advanced from studies with transgenic animals. Interactions between HDL apolipoproteins, transfer proteins, lipolytic enzymes and receptors modulate HDL size, particle number and fractional catabolic rate. The protective effect of HDL on atherosclerosis depends on the combined actions of HDL proteins and the metabolism of apo B-lipoproteins.