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Mechanisms underlying the M-current block by barium in bullfrog sympathetic neurons
S Kotani1, T Hirasawa, T Suzuki
1Department of Physiology, Tokai University School of Medicine, Bohseidai, Isehara, Japan.
Neuroscience Letters
|May 2, 2000
Abstract:
Whole-cell/voltage-clamp recordings were made from dissociated bullfrog sympathetic neurons to examine the channel blocking actions of barium (3-2000 microM) on an M-type potassium current (I(M)). Barium (IC(50) approximately 105 microM) blocked I(M) without affecting the 50%-activation voltage ( approximately -35 mV) and the slope factor ( approximately 11 mV) of the activation curve. The results indicate that the barium block is independent of the kinetics of I(M).