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High-resolution segmented EPI in a motor task fMRI study
F G Hoogenraad1, P J Pouwels, M B Hofman
1Department of Clinical Physics & Informatics, University Hospital Vrije Universiteit, De Boelelaan 1117, P.O. Box 7057, 1007 MB, Amsterdam, The Netherlands. fgc.hoogenraad@azvu.nl
Abstract:
A high-resolution gradient echo, multi-slice segmented echo planar imaging method was used for functional MRI (fMRI) using a motor task at 1.5 Tesla. Functional images with an in-plane resolution of 1 mm and slice thickness of 4 mm were obtained with good white-gray matter contrast. The multi-shot approach, combined with a short total readout period of 82 ms, limits blurring effects for short T(2)(*) tissues (such as gray matter), assuring truly high-resolution images. In all subjects, motor functions were clearly depicted in the contralateral central sulcus over several slices and sometimes activation was detected in the supplementary motor area and/or ipsilateral central sulcus. The average signal change of 11+/-3% was much higher than in standard low-resolution fMRI EPI experiments, as a result of larger relative blood fractions.