Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Aortic valve replacement: is valve size important?

B Medalion1, E H Blackstone, B W Lytle

  • 1Department of Thoracic and Cardiovascular Surgery and the Department of Biostatistics and Epidemiology, The Cleveland Clinic Foundation, Cleveland, Ohio, USA.

The Journal of Thoracic and Cardiovascular Surgery
|May 2, 2000
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Internal mammary artery grafting: The gold standard of coronary revascularization for 40 years and counting.

The Journal of thoracic and cardiovascular surgery·2026
Same author

Endoscopic versus open radial artery harvesting for coronary artery bypass grafting.

The Journal of cardiovascular surgery·2012
Same author

Is gender an independent risk factor for coronary bypass grafting?

The Thoracic and cardiovascular surgeon·2009
Same author

Steep left ventricle to aortic root angle and hypertrophic obstructive cardiomyopathy: study of a novel association using three-dimensional multimodality imaging.

Heart (British Cardiac Society)·2009
Same author

A highly unusual right atrial mass presented in two women.

European journal of echocardiography : the journal of the Working Group on Echocardiography of the European Society of Cardiology·2008
Same author

Cardiac surgery in patients on chronic hemodialysis: short and long-term survival.

The Thoracic and cardiovascular surgeon·2008
Same journal

Bridging Pediatric and Young Adult Cancer Survivorship: Defining the Thoracic Surgeon's Role Across the Continuum.

The Journal of thoracic and cardiovascular surgery·2026
Same journal

Beyond compensatory expansion: Extending 3-dimensional computed tomography volumetry toward lung-preserving local therapy.

The Journal of thoracic and cardiovascular surgery·2026
Same journal

A CALL FOR STANDARDIZATION OF HYBRID ARCH FROZEN ELEPHANT TRUNK OUTCOMES REPORTING.

The Journal of thoracic and cardiovascular surgery·2026
Same journal

Pediatric Mitral Valve Surgery: Current Practice from the European Congenital Heart Surgeons Association Congenital Database Analysis.

The Journal of thoracic and cardiovascular surgery·2026
Same journal

Rethinking Failure to Rescue in Cardiac Surgery.

The Journal of thoracic and cardiovascular surgery·2026
Same journal

Undersized Fontan conduits are not without risk.

The Journal of thoracic and cardiovascular surgery·2026
See all related articles

Aortic valve replacement survival is linked to patient risk factors, not prosthesis size. Moderate patient-prosthesis mismatch does not adversely affect outcomes after aortic valve replacement.

Area of Science:

  • Cardiovascular Surgery
  • Biomedical Engineering
  • Clinical Outcomes Research

Background:

  • Aortic valve replacement (AVR) is a common procedure for aortic stenosis.
  • Prosthesis-patient mismatch (PPM) is a potential concern after AVR.
  • The impact of PPM on long-term survival requires further investigation.

Purpose of the Study:

  • To determine if aortic prosthesis size negatively impacts survival after aortic valve replacement.
  • To analyze the relationship between indexed valve area and patient survival.
  • To assess the influence of patient risk factors on survival post-AVR.

Main Methods:

  • A cohort of 892 adults undergoing primary isolated AVR for aortic stenosis was studied.
  • Patients received mechanical, pericardial, or allograft valves.

Related Experiment Videos

  • Multivariable propensity scores and hazard function analyses were used to adjust for confounders and identify mortality risk factors.

    • Main Results:

    • Twenty-five percent of patients exhibited indexed internal orifice areas more than 2 standard deviations below predicted normal size.
    • Mechanical valves had smaller orifices compared to pericardial or allograft valves.
    • Survival was not adversely affected by moderate patient-prosthesis mismatch (down to approximately 4 SDs below normal).

    Conclusions:

    • Survival after aortic valve replacement is primarily influenced by patient-specific risk factors.
    • Moderate degrees of patient-prosthesis mismatch do not appear to compromise survival.
    • Aortic root enlargement may be necessary in select cases to implant larger prostheses.