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Related Experiment Videos

Thromboembolism in pregnancy.

D M Ramsay

    Obstetrics and Gynecology
    |February 1, 1975
    PubMed
    Summary

    Intravenous heparin effectively treated pregnancy thromboembolic disease. Switching from warfarin to heparin in late pregnancy prevented neonatal bleeding complications, with only minor thrombosis recurrence in one patient.

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    Area of Science:

    • Obstetrics and Gynecology
    • Hematology
    • Pharmacology

    Background:

    • Thromboembolic disease poses risks during pregnancy.
    • Warfarin therapy can lead to neonatal complications.
    • Heparin offers an alternative for managing thromboembolic disorders in pregnant patients.

    Purpose of the Study:

    • To evaluate the safety and efficacy of intravenous heparin for thromboembolic disease in pregnancy.
    • To assess the impact of heparin on neonatal bleeding complications compared to warfarin.

    Main Methods:

    • Eighteen pregnant patients received controlled intravenous heparin infusions.
    • Dosage was adjusted to maintain thrombin time at 2-2.5 times normal.
    • Heparin administration was temporarily halted around delivery to normalize thrombin time.

    Main Results:

    • One patient experienced minor thrombosis recurrence while on warfarin.
    • One patient had significant postpartum bleeding.
    • Substituting heparin for warfarin in late gestation prevented neonatal bleeding.

    Conclusions:

    • Intravenous heparin is a viable treatment for thromboembolic disease in pregnancy.
    • Heparin offers a safer alternative to warfarin, particularly in late gestation, by preventing neonatal bleeding complications.

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