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Factors influencing capping and cracking of mefenamic acid tablets
A Adam1, L Schrimpl, P C Schmidt
1Department of Pharmaceutical Technology, Eberhard-Karls-University Tübingen, Germany.
Drug Development and Industrial Pharmacy
|May 2, 2000
Abstract:
The tendency of capping and longitudinal cracks of mefenamic acid tablets was evaluated in relation to the amount of the binder, the influence of the granulation technique, and the relative humidity of the granules. Tablets made from fluidized bed granules using methylcellulose in the granulating liquid showed significantly lower capping and longitudinal cracks than tablets from conventional granules prepared by wet granulation using methylcellulose as a dry binder.