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[Endothelins--their physiological role and their clinical significance]
K Kaletha1, Z Chodorowski, B Wyrzykowski
1Katedry i Zakładu Biochemii, Akademii Medycznej w Gdańsku.
Przeglad Lekarski
|May 2, 2000
Abstract:
Biochemical part of the paper presents the structure, biosynthesis and degradation of the endothelins. Physiological chapter deals with endothelin-1 endocrine and mitogenic action as well as its impact on diuresis, natriuresis and cardiovascular system. In the clinical part of the article the role of endothelin-1 in essential hypertension, congestive heart failure and chronic renal failure is described.