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Related Experiment Videos

[Herpes Simplex Keratitis under the Scanning lectron Microscope(author's transl)].

F Hoffmann, L Dumitrescu, J Haase

    Albrecht Von Graefes Archiv Fur Klinische Und Experimentelle Ophthalmologie. Albrecht Von Graefe'S Archive for Clinical and Experimental Ophthalmology
    |January 1, 1975
    PubMed
    Summary

    Herpes simplex virus (HSV-1) can cause dendritic keratitis in rabbits, even after ultraviolet (UV) light exposure damages corneal cells. UV treatment did not alter the development of these characteristic viral eye lesions.

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    [Update 2022: interdisciplinary statement on airway management with supraglottic airway devices in pediatric emergency medicine-The laryngeal mask is and remains state of the art : Joint statement of the Institute for Emergency Medicine and Medicine Management (INM), the University Clinic Munich, LMU Munich, Germany, the Working Group for Pediatric Critical Care and Emergency Medicine of the German Interdisciplinary Society for Critical Care and Emergency Medicine (DIVI), the Medical Directors of Emergency Medical Services in Bavaria (ÄLRD), the Scientific Working Group for Pediatric Anesthesia (WAKKA) of the German Society for Anesthesiology and Intensive Care Medicine (DGAI), the Scientific Working Group for Emergency Medicine of the German Society for Anesthesiology and Intensive Care Medicine (DGAI) and the Society of Neonatology and Pediatric Critical Care Medicine (GNPI)].

    Die Anaesthesiologie·2023

    Area of Science:

    • Ophthalmology
    • Virology
    • Microscopy

    Context:

    • Herpes simplex virus type 1 (HSV-1) is a common cause of infectious keratitis.
    • Ultraviolet (UV) radiation can affect corneal epithelial cells.
    • The role of corneal epithelial morphology in HSV-1 keratitis development is not fully understood.

    Purpose:

    • To investigate the effect of ultraviolet (UV) irradiation on the development of dendritic keratitis induced by herpes simplex virus type 1 (HSV-1) in a rabbit model.
    • To examine the corneal lesions using scanning electron microscopy.

    Summary:

    • Dendritic keratitis was induced in rabbits by applying HSV-1 to uviolized and non-uviolized corneas.
    • Scanning electron microscopy revealed dendritic lesions composed of circular foci (100-200 μm).

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  • UV treatment, even causing significant epithelial cell sloughing, did not alter the nature or presence of HSV-1 induced dendritic lesions, challenging the hypothesis of a specific epithelial morphological substrate being the sole inducing factor.

    • Impact:

    • This study suggests that the development of HSV-1 dendritic keratitis is independent of the specific morphological state of the corneal epithelium post-UV exposure.
    • Findings challenge existing theories regarding the direct role of epithelial cell morphology in initiating viral keratitis.
    • Provides insights into the pathogenesis of viral keratitis and potential therapeutic targets.