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Related Experiment Videos

[Heart valve prosthesis and pregnancy].

M Ben-Ismail, M Fekih, M Taktak

    Archives Des Maladies Du Coeur Et Des Vaisseaux
    |February 1, 1979
    PubMed
    Summary
    This summary is machine-generated.

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    Pregnancy with prosthetic heart valves requires careful anticoagulation management. While risks exist, including hemorrhage and fetal loss, continuous anticoagulation, particularly with heparin, is often necessary to prevent thromboembolism.

    Area of Science:

    • Cardiology
    • Obstetrics
    • Pharmacology

    Context:

    • Managing prosthetic heart valves during pregnancy presents unique challenges.
    • Balancing anticoagulation needs with maternal and fetal risks is critical.
    • Existing literature and clinical observations guide management strategies.

    Purpose:

    • To evaluate pregnancy outcomes in patients with prosthetic heart valves under different anticoagulation regimens.
    • To review the risks and benefits of anticoagulation during pregnancy and postpartum.
    • To provide recommendations for optimal anticoagulation management.

    Summary:

    • Outcomes of 16 pregnancies in 13 patients with prosthetic heart valves were analyzed under oral anticoagulation, heparin, or no anticoagulation.
    • While thromboembolism risk was not increased, hemorrhagic complications and fetal loss were significant.

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  • Vitamin-K antagonists showed teratogenicity, though the risk was small.

    • Impact:

    • Anticoagulation management is crucial throughout pregnancy and postpartum due to increased clotting tendency.
    • Heparin is theoretically recommended during the first trimester and late pregnancy/postpartum.
    • Close multidisciplinary supervision and hospitalization are advised for high-risk pregnancies.