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Related Experiment Videos

Oscillations of polymeric microbubbles: effect of the encapsulating shell

Hoff1, Sontum, Hovem

  • 1Norwegian University of Sciene and Technology, Department of Telecommunications, Trondheim.

The Journal of the Acoustical Society of America
|May 2, 2000
PubMed
Summary

A new model describes how encapsulated gas bubbles oscillate, revealing shell properties significantly impact ultrasound contrast agent behavior. The shell

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Area of Science:

  • Acoustic physics
  • Materials science
  • Biomedical engineering

Background:

  • Ultrasound contrast agents utilize encapsulated gas bubbles.
  • Understanding bubble oscillation is crucial for their acoustic behavior.
  • The shell material properties significantly influence bubble dynamics.

Purpose of the Study:

  • To develop a theoretical model for the oscillation of gas bubbles within a thin shell.
  • To apply this model to an experimental ultrasound contrast agent.
  • To estimate the viscoelastic properties of the shell material.

Main Methods:

  • Developed a theoretical model incorporating shell thickness, shear modulus, and shear viscosity.
  • Applied the model to analyze acoustic attenuation measurements of encapsulated air bubbles.

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  • Compared theoretical calculations with experimental data at linear oscillation amplitudes.

    • Main Results:

    • A good fit was achieved between the theoretical model and experimental acoustic attenuation data.
    • Estimated shell shear modulus: 10.6–12.9 MPa.
    • Estimated shell viscosity: 0.39–0.49 Pas.
    • Shell thickness was approximately 5% of the particle radius.
    • Encapsulated bubbles were ~20 times more rigid than free air bubbles.
    • Oscillations were heavily damped with Q-values around 1.

    Conclusions:

    • The encapsulating shell strongly dictates the acoustic behavior of the gas bubbles.
    • Bubble stiffness and viscosity are primarily determined by the shell material, not the gas core.
    • The developed model accurately predicts the behavior of polymer-shelled microbubbles.